Due to the request of many readers, I have added many source codes in the appendix section. This is a revised version of the book. As we know that ultrasound imaging is a boon technology in medical imaging with some limitations as the poor quality of imaging due to speckle noise. Due to this behavior, Doctors and Radiologists feel uncomfortable in diagnosis of a patient because of sometimes clinical details looks like speckle noise or, sometimes speckle noise look like clinical details. That’s why despeckling is very important in ultrasound imaging.