Muralidharan started his professional life as a General Medical Practitioner in Kollengode in 1975. After a short stint as a GP and later as a Medical Officer in Kerala Health Services, he did his post-graduation in Ophthalmology, first at JIPMER, Pondicherry and then at the Calicut Medical College, finishing his MS in 1987. Not long afterwards, he left Government Service and settled down at Palakkad as a General Ophthalmologist. His interests are diverse and include reading, writing, agriculture and association activities. He has served twice as the Secretary of Indian Medical Association, Palakkad Branch and twice as its President. He has self-published a couple of books and writes in English as well as in Malayalam.