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Subrat SaurabhAuthor of Kuch Woh Pal
The interstitial fluid (rSF) of the brain is separated from the blood by the
blood-brain barrier (BBB). This barrier must not be thought of as a single
entity or as an absolute restriction to all molecules, but as a multiple structure
located at several sites within the brain. The first of these interfaces is located
at the endothelium of the brain capillaries. Secondly there is a potential site
for interchange on the outer linings of the brain between the dura and the
arachnoid membranes. Thirdly, there are the choroid plexuses and the
cerebrospinal fluid (CSF) which is in contact with the very permeable internal
ependymal lining of the brain. Finally there are areas of the brain
which lack a blood-brain barrier. These areas constitute the circumventricular
organs and have leaky capillaries with a barrier at the ependyma which
limits the spread of molecules from those regions. Each of these
BBB sites has its own characteristic permeability and transport functions. We
will now consider the properties of each of these barrier sites between the
blood and the brain.
Dr. Mudit Kumar, Dr. Pushpendra Kumar, Dr. Dilpreet Singh
Mudit Kumar is working as a Assitant Professor in Department of Pharmacology, Faculty of Pharmacy UPTUM, Saifai, UP India. He has deep insight into experimental pharmacology and has a 10 year experience in teaching and research. His fields of interest are screening of natural products. He has being published 4 research articles in international and nationa repute journals. He also published some books.
