“What is Tardigrade Damage(Water Bear) suppressor Protein(Dsup)?

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“What is Tardigrade Damage(Water Bear) suppressor Protein(Dsup)? A Unique DNA-associated Protein improves Radiotolerance in Human-cultured cells.’

Author Name: Dr. H. K. Saboowala | Format: Paperback | Genre : Educational & Professional | Other Details

Genomic DNA (Genomic deoxyribonucleic acid is chromosomal DNA, in contrast to extra-chromosomal DNAs like plasmids, abbreviated as gDNA) stores all genetic information and is indispensable for maintenance of normal cellular activity and propagation. Radiation causes severe DNA lesions, including double-strand breaks, and leads to genome instability and even lethality. Regardless of the toxicity of radiation, some organisms exhibit extraordinary tolerance against radiation. • These organisms are supposed to possess special mechanisms to mitigate radiation-induced DNA damages. Extensive study using radio-tolerant bacteria suggested that effective protection of proteins and enhanced DNA repair system play important roles in tolerability against high-dose radiation. Recent studies using an extremotolerant animal, the tardigrade, provides new evidence that a tardigrade-unique DNA-associating protein, termed Dsup, suppresses the occurrence of DNA breaks by radiation in human-cultured cells. An attempt has been made in this Booklet to provide a brief summary of the current knowledge on extremely radiotolerant animals, and present novel insights from the tardigrade research, which expand our understanding on molecular mechanism of exceptional radio-tolerability. ……. Dr. H. K. Saboowala.

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Dr. H. K. Saboowala

A consulting G.P. cum Dermatologist, an editor a nd a globally recognized self-publisher of > 200 E-Medical Booklets as of now, on Amazon kindle with a WORLD RIGHT and an average monthly sell of >20 e- books, having tremendous passion to impart recently updated Medical knowledge to the busy Medicos at one click! .... Dr. H. K. Saboowala. M.B. (Bom) M.R.S.H.(London).