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Subrat SaurabhAuthor of Kuch Woh Pal
olubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired (anticipated) pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. More than 40% NCEs (new chemical entities) developed in pharmaceutical industry are practically insoluble in water. Solubility is a major challenge for formulation scientist. Any drug to be absorbed must be present in the form of solution at the site of absorption. Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include physical and chemical modifications of drug and other methods like particle size reduction, crystal engineering, salt formation, solid dispersion, use of surfactant, complexation, and so forth. Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics.
Dilpreet Singh
Dr. Dilpreet Singh is working as an Associate Professor in ISF College of Pharmacy, Moga. He is a Gold Medalist in B.Pharmacy, University silver medalist in M.Pharmacy and Qualified Graduate Pharmacy Aptitude Test (GPAT) 3 times with Merit Position. He awarded Ph.D. and Post Doc from Guru Nanak Dev University, Amritsar. He also qualified CSIR-NET in December 2019 with Eligibility of Lectureship. His current research interest focus on Bioavailability Enhancement of drugs including Phytochemicals using lipid based technology, Design of Experiments/Quality by Design Paradigms, Systematic Optimization. He had now published 34 publications in International journal of repute. During his research work, he awarded with Homi Bhabha Felowship to collaborate his research work with King’s College London. He qualified CSIR NET (Life sciences), awarded with Lectureship. He is life member of several professional bodies including AAPS, ACS, VERF-T, DDT-I, Boston. He qualified several MOOC courses, credit courses through Swayam UGC Platform and EDX courses through UGETY.
