Between handling cadavers with bare hands, pestering female batch mates as an unknown caller, only to be caught red-handed and to be delivered tongue-lashings by seniors, and a hostel littered with human bones, Gaam, a first-year medical student who has never ventured out of northeastern India before, develops a crush for a north Indian girl; only to be thwarted in his efforts by his flirty room-mate.
He meets the first love of his life – Sonam, an insecure, unpredictable Darjeeling girl – only to add to his confusion, leading to a break up, with no explanation from Sonam.
Gaam's life is forever bombarded with confusing advice from a busy senior and a roommate on how to handle girls.
Will Sonam ever disclose the reason for the break up?
Will Gaam ever learn how to handle women?
Irreverent and humorous, Once Upon a Time in College is replete with Gaam and his friends’ stupid, unforeseen misadventures.